With the pandemic still killing 900 to 1,000 people a day worldwide, the stealthy virus behind COVID-19 hasn't lost its punch. It spreads easily from person to person, riding respiratory droplets in the air, killing some victims but leaving most to bounce back without much harm.
“Whatever the virus is doing today, it’s still working on finding another winning path,” said Dr. Eric Topol, head of Scripps Research Translational Institute in California.
We've become numb to the daily death toll, Topol says, but we should view it as too high. Consider that in the United States, daily hospitalizations and deaths, while lower than at the worst peaks, have not yet dropped to the low levels reached during summer 2021 before the delta variant wave.
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At any moment, the virus could change to become more transmissible, more able to sidestep the immune system or more deadly. Topol said we’re not ready for that. Trust has eroded in public health agencies, furthering an exodus of public health workers. Resistance to stay-at-home orders and vaccine mandates may be the pandemic's legacy.
“I wish we united against the enemy — the virus — instead of against each other," Topol said.
FIGHTING BACK
There's another way to look at it. Humans unlocked the virus' genetic code and rapidly developed vaccines that work remarkably well. We built mathematical models to get ready for worst-case scenarios. We continue to monitor how the virus is changing by looking for it in wastewater.
“The pandemic really catalyzed some amazing science,” said Friedrich.
The achievements add up to a new normal where COVID-19 “doesn’t need to be at the forefront of people’s minds,” said Natalie Dean, an assistant professor of biostatistics at Emory University. “That, at least, is a victory.”
Dr. Stuart Campbell Ray, an infectious disease expert at Johns Hopkins, said the current omicron variants have about 100 genetic differences from the original coronavirus strain. That means about 1% of the virus’ genome is different from its starting point. Many of those changes have made it more contagious, but the worst is likely over because of population immunity.
Matthew Binnicker, an expert in viral infections at Mayo Clinic in Rochester, Minnesota, said the world is in “a very different situation today than we were three years ago — where there was, in essence, zero existing immunity to the original virus.”
That extreme vulnerability forced measures aimed at “flattening the curve.” Businesses and schools closed, weddings and funerals were postponed. Masks and “social distancing” later gave way to showing proof of vaccination. Now, such precautions are rare.